Purdue (4-2) at Ohio State (6-1)

Line: Ohio State by 24.
Saturday, 12:00 ET

Wisconsin just beat up Ohio State. The Buckeyes’ national title hopes are over, and they have nothing to play for. Purdue, meanwhile, has won two in a row. This is the biggest game of the Boilermakers’ season, and I expect them to cover.

Prediction: Ohio State 27, Purdue 17
Purdue +24 (4 Units)

Michigan State (7-0) at Northwestern (5-1)
Line: Michigan State by 5.5.
Saturday, 12:00 ET

Northwestern is a very tough place to play. Back in 2005, when Penn State won the Orangle Bowl, they nearly escaped from Northwestern with a win, having to rely on a last-second touchdown.

These Wildcats are a solid 5-1 and have had two weeks to prepare for this contest. Michigan State, meanwhile, could be looking ahead to Iowa next Saturday.

Prediction: Northwestern 27, Michigan State 23
Northwestern +5.5 (3 Units)

Wyoming (2-5) at BYU (2-5)
Line: BYU by 10.5.
Saturday, 2:00 ET

Why is BYU favored by double digits? Since their opener, the Cougars have outgained only one team. There is no reason they should be giving more than six points in this matchup.

Prediction: BYU 21, Wyoming 17
Wyoming +10.5 (3 Units)

Arizona State (3-3) at California (3-3)

Line: California by 3.
Saturday, 3:30 ET

This is a tough spot for Cal. They’re coming off a tough loss to USC and could be flat against an Arizona State squad that has had two weeks to prepare for this contest.

Prediction: Arizona State 27, California 21
Arizona State +3 (4 Units)

Oklahoma (6-0) at Missouri (6-0)

Line: Oklahoma by 3.
Saturday, 8:00 ET

Can someone tell me why Oklahoma is first in the BCS poll? Didn’t they nearly lose to Cincinnati and Air Force? The Sooners are a bit of a fraud, and I think they’ll get hammered at Missouri this Saturday. The Tigers are coming off a win on the road and are now underdogs under the lights with the Game Day crew on site. That’s usually a recipe for success.

Prediction: Missouri 34, Oklahoma 24
Missouri +3 (2 Units)

via WalterFootball.com: NCAA College Football Picks – Week 8, 2010.